FORMULASI DAN EVALUASI GRANUL DISPERSI PADAT EKSTRAK KITOSAN CANGKANG KEPITING BAKAU (Scylla serrata) DENGAN PERBANDINGAN KITOSAN:PVP K-30 1:2

Hannah Savitri Abdullah; Hilya Nur Imtihani

doi:10.37089/jofar.vi0.119

Hannah Savitri Abdullah rogram Studi Diploma III Farmasi Akademi Farmasi Surabaya
Hilya Nur Imtihani rogram Studi Diploma III Farmasi Akademi Farmasi Surabaya

DOI: https://doi.org/10.37089/jofar.vi0.119

Keywords: Chitosan, Granules, PVP K-30, Solid dispersion, Scylla serrata

Abstract

Background: Mangrove crab shells (Scylla serrata) contain chitosan which functions as an anticholesterol. Chitosan is insoluble in water but soluble in acids such as acetic acid. In the process of increasing the solubility, a solid dispersion system is made. The solid dispersion is then formulated into granules. Objective: The purpose of this study was to determine the physical properties of the solid dispersion chitosan granules (FI) and the physical mixture granules (FII). Methods: The method used for the manufacture of solid dispersions is solvent evaporation using PVP K-30 (1:2) as a carrier. The solid dispersion will be made in the form of granules by wet granulation method which will then evaluate the quality of the granules. Results: From this study, the granule flow rate FI=12.89 g/second, and FII=24.58 g/second. The angle of repose of the granules FI=22,13o, and FII=9,46o. The compressibility and Hausner granule FI ratio were found to be 20% and 1.25; while FII obtained 9.90% and 1.11. The percentage of water content of FI granules is 6.38%, and FII is 2.04%. Conclusion: The formulation in this study was able to produce granules that met the requirements, and there was a significant difference between the physical properties of FI and FII granules.

References

Agustina, S., Swantara, I. M. D. dan Suartha, I. N., 2015, Isolasi Kitin, Karakterisasi, dan Sintesis Kitosan dari Kulit Udang, Jurnal Kimia, 9(2), 271–278.
Ansel, H. C., Allen L.V., Popovich N. G., 2011, Ansel ’ s Pharmaceutical Dosage Forms and Drug Delivery Systems. 9 ed. Diedit oleh D. B.Troy. New York: Lippincott Williams & Wilkins.
Ardiani, W. P., 2012, Perbandingan Variasi Suhu Pengeringan Granul Terhadap Kadar Air dan Sifat Fisis Tablet Parasetamol, Jurnal Fakultas Matematika dan Ilmu Pengetahuan Alam.
Aulton, M. E.,2002, Pharmaceutics : the science of dosage form design. Churchill Livingstone.
Bokura, H. dan Kobayashi, S., 2003, Chitosan decreases total cholesterol in women: A randomized, double-blind, placebo-controlled trial, European Journal of Clinical Nutrition, 57(5), 721–725. doi: 10.1038/sj.ejcn.1601603.
Chokshi, R. J. et al., 2007, Improving the dissolution rate of poorly water soluble drug by solid dispersion and solid solution - Pros and cons,” Drug Delivery, 14(1), 33–45. doi: 10.1080/10717540600640278.
Husni, P., Fadhiilah, M. L. dan Hasanah, U., 2020, Formulasi dan Uji Stabilitas Fisik Granul Instan Serbuk Kering Tangkai Genjer (Limnicharis flava (L.) Buchenau.) Sebagai Suplemen Penambah Serat, Jurnal Ilmiah Farmasi Farmasyifa, 3(1), 1–8.
Kim, K.-T. et al., 2011, Solid Dispersions as a Drug Delivery System, Journal of Pharmaceutical Investigation, 41(3), 125–142. doi: 10.4333/kps.2011.41.3.125.
Kusumawati, W., 2012, Perbandingan Lama Pengeringan Granul Terhadap Kadar Air dan Sifat Fisis Tablet Parasetamol, Jurnal Fakultas Matematika dan Ilmu Pengetahuan Alam.
Laksmitawati, D. R. et al., 2017, Optimasi Konsentrasi Ekstrak dan Bahan Pengikat Polivinil Pirolidon pada Granul Ekstrak Daun Sirih Merah (Piper crocatum Ruiz & Pav) sebagai Antihiperurisemia, Ilmu Kefarmasian Indonesia, 15(2), 216–222.
Maidin, A. N., 2017, Produksi Kitosan dari Limbah Cangkang Kepiting Rajungan (Portunidae) Secara Enzimatis dan Aplikasinya Sebagai Penurun Kolestrol, Tesis, Universitas Hasanudddin. Universitas Hasanudddin.
Mulyadi, M. D., Astuti, I. Y. dan Dhiani, B. A., 2011, Formulasi Granul Instan Jus Kelopak Bunga Rosela (Hibiscus sabdariffa L) Dengan Variasi Konsentrasi Povidon Sebagai Bahan Pengikat Serta Kontrol Kualitasnya,” Pharmacy, 08(03), 29–41.
Murtini, G. dan Elisa, Y., 2018, Teknologi Sediaan Solid. 2018 ed. Diedit oleh E. Krisnadi, B. A. Darmanto, dan F. H. Pohan. Kementerian Kesehatan Republik Indonesia. Jakarta, hal 84.
Prayogo, D. S., 2014, Pembuatan Tablet Salut Film Sambung Silang Kitosan – Tripolifosfat dengan Metode Semprot, Skripsi, Program Studi Farmasi, UIN Syarrif Hidayatullah, Jakarta.
Rochmawati, Z. N., Nabila, F. dan Ainurrohmah, C., 2018, Karakterisasi Kitosan Yang Diisolasi Dari Cangkang Internal Cumi-Cumi,” Karakterisasi Kitosan Yang Diisolasi Dari Cangkang Internal Cumi-Cumi, 16(1), 3. doi: 10.15294/sainteknol.v16i1.15048.
Rowe, R. C., Sheskey, P. J. dan Quinn, M. E., 2009, Handbook of Pharmaceutical Excipients. 6 ed, Pharmaceutical Press. Chicago, hal 283.
Safitri, N. R. D., Dali, S. dan Fawwaz, M., 2016, Isolasi Kitosan dari Limbah Cangkang Kepiting Bakau (Scylla serrata) dan Aplikasinya terhadap Penyerapan Trigliserida,” As-Syifaa, 08(02), 2.
Salman, Meryza dan Noviza, D., 2013, Formulasi Granul Mukoadhesif Dispersi Padat Ketoprofen – PVP K- 30 Menggunakan Kitosan,” Jurnal Sains dan Teknologi Farmasi, 18(1), 49–55.
SNI 01-2891-1992 (tanpa tanggal) Kadar Air Metode Oven dan Kadar Abu. Bekasi. Tersedia pada: https://adoc.pub/a-kadar-air-sni-metode-oven-b-kadar-abu-sni-abu-total.html (Diakses: 2 September 2021).
Trianggani, D. F. dan Sulistiyaningsih, 2018, Artikel tinjauan: Dispersi padat,” Farmaka, 16(1), 93–102.
Umar, S., Sari, N. V. dan Azhar, R., 2014, Studi Kestabilan Fisika Dan Kimia Dispersi Padat Ketoprofen–Polivinil Pirolidon K-30,” Jurnal Farmasi Higea, 6(1), 3.
Wahyuni, 2016, Pemanfatan Pati Umbi Tire (Amorphophallus onchopillus) Sebagai Bahan Pengikat Tablet Parasetamol dengan Metode Granulasi Basah. Tesis, Jurusan Farmasi, UIN Alauddin, Makassar.
Yusuf, N. A. dan Layuk, L. V. L., 2017, Formulasi Granul Mukoadhesif Ekstrak Etanol Rimpang Lakka-Lakka (Curculigo Orchioides G.) dengan Variasi Konsentrasi Polimer HPMC-Karbopol,” Pharmauho, 3(1), 33–38.