FORMULASI DAN KARAKTERISASI MIKROEMULGEL ETIL P-METOKSISINAMAT (EPMS) DARI RIMPANG KENCUR (Kaempferia galanga Linn)

Framesti Frisma Sriarumtias; Raden Aldizal  Mahendra Rizkio Syamsudin; Liyatul  Ummah; Fajar Fauzi  Abdillah

doi:10.37089/jofar.vi0.106

Framesti Frisma Sriarumtias Universitas Garut
Raden Aldizal Mahendra Rizkio Syamsudin Program Studi Farmasi, Universitas Garut
Liyatul Ummah Program Studi Farmasi, Universitas Garut
Fajar Fauzi Abdillah Program Studi Farmasi, Universitas Garut

DOI: https://doi.org/10.37089/jofar.vi0.106

Abstract

Ethyl p-methoxycinnamate (EPMC) is the main compound from the rhizome of kencur (Kaempferia galanga Linn) isolated with a non-polar solvent, n-hexane. Several studies have proven that EPMC has a pharmacological effect as an anti-inflammatory. The purpose of this study was to make a topical formulation of EPMC using microemulgel preparations. The method used in the manufacture of microemulsions is to make a spontaneous microemulsion system and load it into a gel base. The oil phase used is isopropyl myristate, the surfactant used is tween 80, cosurfactant ethanol 96%, gelling agent is carpopol 340, triethanolamine (TEA) as a base and propylene glycol as a humectant. The dose of EPMC used was 200 g/mL. Four microemulgel formulations have been made, namely B1, B2, B3 and B4 with various concentrations of surfactant and cosurfactant. The results showed that the best formula was B3 formula with 5% isopropyl myristate, 40% Tween 80, 10% ethanol 96%, 10% propylene glycol, 1% carbopol, TEA and aquades. The conclusion of this formula is that the use of surfactants and cosurfactants in large quantities makes a transparent appearance and better stability than other formulations.

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